Key result
cFFR outperforms Pd/Pa and iFR in predicting FFR with ~85% agreement.
Why the study?
Does cFFR provide superior diagnostic performance compared to Pd/Pa or iFR for predicting FFR?
Does cFFR provide superior diagnostic performance compared to Pd/Pa or iFR for predicting FFR?
cFFR offers a simplified alternative for invasive coronary physiological assessment when adenosine is contraindicated or prohibitively expensive, though FFR remains the reference standard.
cFFR may support adenosine-free assessment; extends observational comparisons yet leaves open randomized outcome validation.
cFFR provides diagnostic performance superior to that of Pd/Pa or iFR for predicting FFR. For clinical scenarios or health care systems in which adenosine is contraindicated or prohibitively expensive, cFFR offers a universal technique to simplify invasive coronary physiological assessments. Yet FFR remains the reference standard for diagnostic certainty as even cFFR reached only ∼85% agreement.
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Johnson et al. (2016) studied this question. cFFR demonstrated superior performance compared to Pd/Pa or iFR in predicting FFR, achieving approximately 85% agreement with the reference standard.
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