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January 22, 2026Food Science & NutritionOpen Access

Programmed Sequential Release Behavior and Bioavailability of Curcumin and Fucoxanthin Co‐Encapsulated in Solid‐In‐Oil‐In‐Water Multilayer Emulsions

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Authors

LWLuhui WangMWMingqing WangLLLing Lv

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Overview

Demonstrates enhanced bioavailability of curcumin and controlled release of fucoxanthin using multilayer emulsions, implying improved delivery in the gastrointestinal tract.

Key Points

  • The research aims to evaluate the programmed release and bioavailability of curcumin and fucoxanthin using solid-in-oil-in-water multilayer emulsions.
  • Constructed solid-in-oil-in-water multilayer emulsions for co-encapsulation of curcumin and fucoxanthin.
  • Evaluated release behavior through in vitro digestion models.
  • Assessed in vivo bioavailability using fluorescence imaging.
  • Less than 16.5% of curcumin and fucoxanthin were released in simulated gastric fluid.
  • Curcumin was released in 67.3% during simulation of intestinal fluid due to erosion.
  • 60.3% of fucoxanthin was released into simulated colonic fluid, primarily through erosive mechanisms.
  • Curcumin bioavailability was enhanced by 6.4-fold in the small intestine.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6971be6b642b1836717e31a7https://doi.org/10.1002/fsn3.71463
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