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This research aims to assess how COVID-19 affects outcomes and resource use in diabetic ketoacidosis (DKA) hospitalizations.

COVID ‐19 and diabetic ketoacidosis: National outcomes, predictors, and resource utilization in the United States

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National analysis reveals COVID‐19 worsens diabetic ketoacidosis outcomes and increases healthcare demands.

This research aims to assess how COVID-19 affects outcomes and resource use in diabetic ketoacidosis (DKA) hospitalizations.
Analyzed DKA hospitalizations in the U.S. from 2020–2021 National Inpatient Sample.
Primary outcome was in-hospital mortality; secondary outcomes were AKI, mechanical ventilation, and others.
Used multivariable regression and propensity score matching to adjust for various factors.
Among 658,675 DKA hospitalizations, 69,005 involved COVID-19 (10.5%).
COVID-19 associated with 21.3% in-hospital mortality compared to 3.4% without (P < 0.001).
Adjusted analysis shows COVID-19 linked to over sixfold higher mortality (aOR 6.22).
Increased risks for AKI, ventilation, sepsis, and vasopressor use; longer LOS and higher costs observed.

Cho et al. (2026) studied this question.

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