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September 21, 2022South African Family PracticeOpen Access

Among 10 patients admitted with COVID-19 and diabetic ketoacidosis, all had type 2 diabetes or newly diagnosed diabetes, and the mortality rate was 30%, with hypoxia being a strong predictor of death.

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Why the study?

COVID-19 increases DKA prevalence and mortality, but data on DKA and COVID-19 at the district hospital level in South Africa are limited.

Population

10 patients presenting with DKA and COVID-19 infection at a district hospital in South Africa

Design

Case series

Key result

Among 10 patients admitted with COVID-19 and diabetic ketoacidosis, all had type 2 diabetes or newly diagnosed diabetes, and the mortality rate was 30%, with hypoxia being a strong predictor of death.

Authors

HDHeather N. DicksKNKeshena Naidoo

Discussion

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Member takes

Overview

meaning:* Leaves open whether this association holds in larger cohorts.

Study Design

Type

Observational (n=10)

Multicenter

No

Structured PICO

P
Population
10 adult patients with diabetic ketoacidosis and concurrent COVID-19 infection admitted to an urban district hospital in South Africa.
O
Outcome
Clinical characteristics, biochemical results, comorbidities, and clinical outcomes (mortality)hard clinical

In a South African district hospital, DKA in COVID-19 patients occurred predominantly in young individuals with type 2 diabetes and suboptimal glycemic control, with hypoxia being a strong predictor of mortality.

Limitations

  • Small sample size, making the characteristics of this cohort not statistically significant
  • Convenience sample from one facility that may not be representative of all patients with DKA and COVID-19
  • Conducted during the height of the COVID-19 pandemic, where staff shortages and resource changes may have influenced inpatient management and clinical outcomes
  • Small sample size
  • Convenience sample from one facility
  • May not be representative of all patients with DKA and COVID-19
  • Conducted during the height of the COVID-19 pandemic where staff shortages and resource changes may have influenced management and outcomes

Cite This Study

Dicks et al. (2022) conducted an observational in Diabetic ketoacidosis and COVID-19 (n=10). COVID-19 infection with diabetic ketoacidosis was evaluated on Mortality. Among 10 patients admitted with COVID-19 and diabetic ketoacidosis, all had type 2 diabetes or newly diagnosed diabetes, and the mortality rate was 30%, with hypoxia being a strong predictor of death.

synapsesocial.com/papers/6a8dfefd4de0b838a62017dbhttps://doi.org/10.4102/safp.v64i1.5590
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of COVID-19 on the clinical course of diabetic ketoacidosis (DKA) in people with type 1 and type 2 diabetes2021 · 31 citations
  2. 2Diabetic ketoacidosis after COVID-19 infection in newly diagnosed patients with diabetes in the Middle East and African countries: A systematic review and meta-analysis2026
  3. 3Clinical presentation and outcomes of care in adults with diabetic ketoacidosis pre-COVID-19 and during-COVID-19 at a tertiary, referral hospital in Nairobi, Kenya2024 · 3 citations
  4. 412469 Impact Of Covid-19 Infection On Diabetic Ketoacidosis Severity And Outcomes In Adult Population- A Retrospective Observational Study2024
  5. 5<scp>COVID</scp> ‐19 and diabetic ketoacidosis: National outcomes, predictors, and resource utilization in the United States2026