What question did this study set out to answer?

Identify risk factors for intestinal fibrosis in patients with Crohn’s disease and ulcerative colitis in Sweden.

January 23, 2026Journal of Crohn s and Colitis

P1259Risk factors for intestinal fibrosis on mucosal biopsies in patients with inflammatory bowel disease in Sweden: a cohort study

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Authors

JSJ SunKarolinska Institutet MLM LiKarolinska Institutet BRBjörn RoelstraeteKarolinska Institutet

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Implication

A cohort study identifies complications linked to fibrosis in patients with Crohn’s disease and ulcerative colitis, suggesting important medical implications.

Key Points

Identify risk factors for intestinal fibrosis in patients with Crohn’s disease and ulcerative colitis in Sweden.
Nationwide cohort study of patients with incident Crohn's disease and ulcerative colitis from 1990 to 2023
Patients identified from the National Patient Register and gastrointestinal histopathology cohort
Cox proportional hazards models used to estimate hazard ratios for risk factors associated with fibrosis
653 patients with intestinal fibrosis identified among 26,328 with Crohn's disease
Significant factors for fibrosis include older age, autoimmune diseases, and specific surgeries
1,004 patients with intestinal fibrosis among 52,039 with ulcerative colitis
Medication use (PPIs, 5-ASA for CD; anti-TNFα, corticosteroids for UC) associated with increased fibrosis risk

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69730eabc8125b09b0d1e890 https://doi.org/10.1093/ecco-jcc/jjaf231.1440

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Implication

A cohort study identifies complications linked to fibrosis in patients with Crohn’s disease and ulcerative colitis, suggesting important medical implications.

P1259Risk factors for intestinal fibrosis on mucosal biopsies in patients with inflammatory bowel disease in Sweden: a cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

P1259Risk factors for intestinal fibrosis on mucosal biopsies in patients with inflammatory bowel disease in Sweden: a cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

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