What question did this study set out to answer?

This research aims to identify a serum lipidomic signature that can differentiate individuals with inflammatory bowel disease from symptomatic controls.

January 23, 2026Journal of Crohn s and Colitis

P0510Non-targeted lipidomic profiling reveals distinct molecular signatures in inflammatory bowel disease: Discovery and validation in two inception cohorts

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Authors

SSS SalihovicÖrebro University OØO ØyåsOslo University Hospital SHS Hyll HansenOslo University Hospital

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Implication

Lipidomic profiling reveals a diagnostic signature for IBD in two cohorts, implying enhanced detection capabilities.

Key Points

This research aims to identify a serum lipidomic signature that can differentiate individuals with inflammatory bowel disease from symptomatic controls.
Conducted untargeted lipidomic profiling on serum samples from two independent cohorts.
Utilized supervised machine-learning models to identify candidate diagnostic lipids in the discovery cohort.
Evaluated diagnostic performance of identified lipids in conjunction with inflammatory markers like hs-CRP and fecal calprotectin.
The lipidomic signature showed high diagnostic accuracy in the discovery cohort (AUC 0.80).
Combination of the lipid signature with hs-CRP improved discrimination between IBD and controls (AUC 0.79).
Integrating fecal calprotectin with lipid and hs-CRP further enhanced diagnostic accuracy (AUC 0.89).

Cite This Study

Salihovic et al. (2026) studied this question.

synapsesocial.com/papers/69730fc4c8125b09b0d1f898 https://doi.org/10.1093/ecco-jcc/jjaf231.691

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P0510Non-targeted lipidomic profiling reveals distinct molecular signatures in inflammatory bowel disease: Discovery and validation in two inception cohorts

Discussion

Member takes

Implication

Key Points

Cite This Study

P0510Non-targeted lipidomic profiling reveals distinct molecular signatures in inflammatory bowel disease: Discovery and validation in two inception cohorts

Discussion

Member takes

Implication

Key Points

Cite This Study

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