What question did this study set out to answer?

This study investigates the salivary microbiota in inflammatory bowel disease and explores how 5-ASA treatment impacts microbiota composition and oral health.

January 23, 2026Journal of Crohn s and Colitis

P1325 Salivary microbiota dysbiosis in Inflammatory Bowel Disease: impact of 5-ASA and oral inflammation

View Full Paper

Ask AI

Bookmark

Authors

RGRubina GomesPolytechnic Institute of Viseu RMR MirandaInstituto Português de Oncologia Francisco Gentil AGA GomesUniversidade Católica Portuguesa

Discussion

Member takes

Implication

This research demonstrates the link between oral dysbiosis and inflammatory bowel disease, suggesting implications for management strategies.

Key Points

This study investigates the salivary microbiota in inflammatory bowel disease and explores how 5-ASA treatment impacts microbiota composition and oral health.
Collected saliva samples from controls and IBD patients and stored at -80 °C until processing.
Sequenced the V4 region of the 16S rRNA gene using Illumina MiSeq.
Analyzed sequences in QIIME2 for taxonomic assignment and diversity metrics.
Assessed differential abundance with ANCOM-BC2 and performed further analyses in R.
The salivary microbiota composition significantly differed between controls and IBD patients (P = 0.001).
IBD patients exhibited higher α-diversity than controls (P = 0.000).
5-ASA treatment led to compositional shifts and a reduction in IBD-associated pathobionts (P = 0.037).
Periodontal inflammation in IBD cases was linked to reduced α-diversity (P = 0.007).

Cite This Study

Gomes et al. (2026) studied this question.

synapsesocial.com/papers/69730ed4c8125b09b0d1eaf7 https://doi.org/10.1093/ecco-jcc/jjaf231.1506

View Full Paper

Ask AI

Bookmark

Implication

This research demonstrates the link between oral dysbiosis and inflammatory bowel disease, suggesting implications for management strategies.

P1325 Salivary microbiota dysbiosis in Inflammatory Bowel Disease: impact of 5-ASA and oral inflammation

Discussion

Member takes

Implication

Key Points

Cite This Study

P1325 Salivary microbiota dysbiosis in Inflammatory Bowel Disease: impact of 5-ASA and oral inflammation

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider