What question did this study set out to answer?

This research aims to characterize and compare the immune landscape across different ileal layers in Crohn’s disease.

P0169The transcriptomic immune profiling across the different Ileal Layers Highlights the Relevant Role of Neutrophils and the active involvement of Healthy Mucosa in Human Crohn’s Disease

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Explores immune responses in Crohn’s disease by analyzing transcriptomic profiles in ileal tissues, suggesting new treatment pathways.

This research aims to characterize and compare the immune landscape across different ileal layers in Crohn’s disease.
Dissected ileal samples from patients with diagnosed Crohn's disease into mucosa, submucosa, and serosa layers.
Quantified relative mRNA copies for 579 human genes using the nCounter® GX Human Immunology V2 kit.
Conducted comparison of gene expression profiles between diseased and adjacent healthy tissues.
Significant transcriptional dysregulation observed in the mucosa of Crohn's disease patients.
Innate immunity genes were upregulated in damaged mucosa, with notable neutrophil-related transcripts in damaged serosa.
Healthy ileal tissue mirrored the immune cell distribution of diseased ileum, indicating a potential role in Crohn's disease pathogenesis.
Evidence of a gradient of immune activity from mucosa to serosa in both tissue types.

Nannini et al. (2026) studied this question.

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