What question did this study set out to answer?

To elucidate the immune mechanisms underlying mucosal inflammation in Crohn's disease by comparing local intestinal and systemic immune profiles.

June 4, 2025Open Access

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn’s disease

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To elucidate the immune mechanisms underlying mucosal inflammation in Crohn's disease by comparing local intestinal and systemic immune profiles.
Performed single-cell RNA sequencing on paired terminal ileum mucosal biopsies and peripheral blood samples from 125 patients with Crohn’s disease.
Immune cell transcriptional profiles are predominantly dictated by the local tissue microenvironment, with mucosal immune cells exhibiting extensive inflammation-associated alterations that are largely absent in general circulation.
A subset of circulating T cells exhibiting a tissue-resident memory-like phenotype mirrors mucosal inflammation, showing pronounced enrichment in interferon gamma and TNF receptor signaling pathways.

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Implication

Single-cell profiling uncovers tissue-specific immune signatures in Crohn’s disease, revealing circulating memory T cells that track mucosal inflammation.

Cite This Study

Ramirez-Navarro et al. (2025) studied this question.

synapsesocial.com/papers/6a0da69f6e03bc61cb09d9af https://doi.org/10.1101/2025.06.03.25328858

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Implication

Single-cell profiling uncovers tissue-specific immune signatures in Crohn’s disease, revealing circulating memory T cells that track mucosal inflammation.

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn’s disease

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Discussion

Implication

Cite This Study

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn’s disease

Key Points

Discussion

Implication

Cite This Study

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