What question did this study set out to answer?

This study aims to characterize the immune landscape of different ileal layers in Crohn’s disease, focusing on the role of neutrophils and healthy mucosa.

March 14, 2026Immunology LettersOpen Access

The transcriptomic immune profiling across the different Ileal Layers Highlights the Relevant Role of Neutrophils and the active involvement of Healthy Mucosa in Human Crohn’s Disease

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This study aims to characterize the immune landscape of different ileal layers in Crohn’s disease, focusing on the role of neutrophils and healthy mucosa.
Conducted gene expression profiling of ileal wall layers in Crohn's disease patients.
Dissected ileal samples into mucosa, submucosa, and serosa from 17 patients.
Utilized NanoString nCounter® GX Human Immunology V2 kit to quantify immune-related gene expression.
Identified distinct transcriptional profiles between diseased and healthy tissues across all layers.
Damaged mucosa showed significant upregulation of innate immunity-related genes.
Neutrophil-related transcripts predominated in the serosa, indicating their role in disease progression.

Authors

GNG NanniniUniversity of Florence FGF GiudiciUniversity of Florence FDFink DorianUniversity of Florence

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Implication

Immune profiling reveals neutrophils' role in Crohn's disease and involvement of healthy mucosa.

Cite This Study

Nannini et al. (2026) studied this question.

synapsesocial.com/papers/69b4fb1bb39f7826a300bb4a https://doi.org/10.1016/j.imlet.2026.107168

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The transcriptomic immune profiling across the different Ileal Layers Highlights the Relevant Role of Neutrophils and the active involvement of Healthy Mucosa in Human Crohn’s Disease

Key Points

Discussion

Implication

Cite This Study

The transcriptomic immune profiling across the different Ileal Layers Highlights the Relevant Role of Neutrophils and the active involvement of Healthy Mucosa in Human Crohn’s Disease

Key Points

Discussion

Implication

Cite This Study

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