What question did this study set out to answer?

The study aims to examine the relationship between maternal fish consumption during pregnancy and the subsequent risk of inflammatory bowel disease in offspring, along with metabolite profile alterations.

January 23, 2026Journal of Crohn s and Colitis

P1189Maternal fish intake during pregnancy is associated with reduced offspring Inflammatory Bowel Disease risk and metabolic profile alterations

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The study aims to examine the relationship between maternal fish consumption during pregnancy and the subsequent risk of inflammatory bowel disease in offspring, along with metabolite profile alterations.
Analyzed maternal and offspring data from the Danish National Birth Cohort and National Patient Register.
Evaluated maternal fish intake using food frequency questionnaires and categorized by tertiles.
Followed offspring for inflammatory bowel disease diagnosis until age 18.
Conducted metabolite profile analysis using dried blood spots collected at birth.
High total fish intake was associated with a 39% reduced risk of inflammatory bowel disease compared to low intake.
Average fish intake correlated with a 35% reduced risk of inflammatory bowel disease.
Specific reductions in Crohn's disease (CD) and ulcerative colitis (UC) risk associated with lean fish and omega-3 intakes were noted.
Maternal fish intake correlated with changes in 64 offspring metabolites but none were linked to inflammatory bowel disease risk.

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Implication

Findings reveal reduced inflammatory bowel disease risk in offspring associated with maternal fish intake during pregnancy, suggesting dietary influence.

Cite This Study

Ciobotaru et al. (2026) studied this question.

synapsesocial.com/papers/69730f78c8125b09b0d1f334 https://doi.org/10.1093/ecco-jcc/jjaf231.1370

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Implication

Findings reveal reduced inflammatory bowel disease risk in offspring associated with maternal fish intake during pregnancy, suggesting dietary influence.

P1189Maternal fish intake during pregnancy is associated with reduced offspring Inflammatory Bowel Disease risk and metabolic profile alterations

Key Points

Discussion

Implication

Cite This Study

P1189Maternal fish intake during pregnancy is associated with reduced offspring Inflammatory Bowel Disease risk and metabolic profile alterations

Key Points

Discussion

Implication

Cite This Study