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January 23, 2026Journal of Biochemical and Molecular Toxicology

Overexpression of TFPI‐2 Suppresses Colorectal Cancer Progression by Inducing Ferroptosis via NF‐κB Signaling

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Authors

XSXiaojing ShiXinyang Central HospitalBSBo SongQingdao UniversityJLJianQi LuXinxiang Medical University

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Implication

The study demonstrates that TFPI-2 induces ferroptosis in colorectal cancer, suggesting potential therapeutic implications.

Key Points

  • This research aims to explore the role of TFPI-2 in colorectal cancer and its impact on ferroptosis through NF-kB signaling.
  • Assessed TFPI-2 expression in CRC tissues using IHC, RT-qPCR, and Western blot.
  • Silenced or overexpressed TFPI-2 in CRC cells via plasmid transfection.
  • Conducted functional assays including CCK-8, EdU staining, and Transwell assays.
  • Evaluated ferroptosis indicators like ROS and Fe²⁺ levels.
  • Investigated NF-kB signaling pathway using an NF-kB inhibitor in cell treatments.
  • Overexpressing TFPI-2 suppressed CRC cell growth, invasion, and EMT.
  • TFPI-2 knockdown worsened malignant characteristics in CRC cells.
  • In vivo studies confirmed TFPI-2's tumor-suppressive effects using xenograft models.
  • Knocking down TFPI-2 reduced ferroptosis by enhancing NF-kB pathway activity.

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/69730f78c8125b09b0d1f4d2https://doi.org/10.1002/jbt.70703
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