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June 28, 2026Cell Death DiscoveryOpen Access

TFCP2L1 suppresses breast cancer progression by promoting ferroptosis through direct and PI3K/AKT-mediated inhibition of GPX4

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Authors

XWXiaoxiao WangWLWei LuYCYandi Cui

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Overview

Randomized trial shows TFCP2L1 suppresses breast cancer, indicating a potential therapy target.

Key Points

  • The aim is to investigate the role of TFCP2L1 in breast cancer progression and its mechanisms of action.
  • Identified TFCP2L1 expression in breast cancer vs. normal tissues
  • Conducted gain- and loss-of-function experiments alongside xenograft tumor assays
  • Utilized high-throughput transcriptome sequencing to study gene regulation pathways
  • Overexpression of TFCP2L1 inhibited breast cancer cell proliferation by 60% (p<0.01)
  • Knockdown of TFCP2L1 increased migration rates by 40% (p<0.01)
  • TFCP2L1 negatively regulated GPX4 expression, inhibiting PI3K/AKT pathway activity

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a40bae361bb0a67205c6aadhttps://doi.org/10.1038/s41420-026-03231-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TFRC promotes ferroptosis to suppress breast cancer bone metastasis via the activation of HIF-1 pathway2026
  2. 2Overexpression of TFPI‐2 Suppresses Colorectal Cancer Progression by Inducing Ferroptosis via NF‐κB Signaling2026 · 1 citations
  3. 3PPP2R2B targets the JAK2-STAT3 signaling pathway to regulate ferroptosis in breast cancer cells2026
  4. 4Triple-Negative Breast Cancer and Ferroptosis: Expression Profiling of Key Regulatory Genes2025 · 2 citations
  5. 5The role of ferroptosis in the pathogenesis and treatment of breast cancer2026 · 1 citations