Radical Cascade Cyclization of 3-Allyl-2-arylquinazolinones Mediated by Silver(I) Salts to Access SCF₃/SCN-Enriched Dihydroisoquinolino[1,2-b]quinazolinones

Vijay Vara; Muthukrishnan Murugan; Kishor R. Thete; Akram A Khan

doi:10.1039/d5ob01755f

January 1, 2025Organic & Biomolecular Chemistry

Radical Cascade Cyclization of 3-Allyl-2-arylquinazolinones Mediated by Silver(I) Salts to Access SCF₃/SCN-Enriched Dihydroisoquinolino[1,2-b]quinazolinones

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Key Points

This research aims to develop a method for synthesizing SCF₃- and SCN-functionalized dihydroisoquinolino[1,2-b]quinazolinones using radical chemistry.
Utilized silver(I) salts as a mediator in the reaction process.
Employed radical-mediated 1,2-difunctionalization of allylic alkenes.
Followed up with intramolecular cyclization to form polycyclic structures.
Successfully synthesized SCF₃- and SCN-functionalized dihydroisoquinolino compounds.
Demonstrated efficiency in transforming allylic alkenes through a radical pathway.
Achieved enhanced structural complexity in the final products.

Implication

An efficient synthesis approach reveals SCF₃/SCN-enriched compounds, suggesting broader applications in organic chemistry.

Abstract

Herein, we describe an efficient approach for the synthesis of SCF₃-and SCN-functionalized polycyclic Dihydroisoquinolino[1,2-b]quinazolinones through radical-mediated 1,2-difunctionalization of allylic alkenes followed by intramolecular cyclization. The transformation proceeds through sulfur-radical-triggered C-S...

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Cite This Study

Vara et al. (2025) studied this question.

synapsesocial.com/papers/69730fc4c8125b09b0d1f78f https://doi.org/10.1039/d5ob01755f

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Radical Cascade Cyclization of 3-Allyl-2-arylquinazolinones Mediated by Silver(I) Salts to Access SCF₃/SCN-Enriched Dihydroisoquinolino[1,2-b]quinazolinones

Key Points

Implication

Abstract

Discussion

Cite This Study

Radical Cascade Cyclization of 3-Allyl-2-arylquinazolinones Mediated by Silver(I) Salts to Access SCF₃/SCN-Enriched Dihydroisoquinolino[1,2-b]quinazolinones

Key Points

Implication

Abstract

Discussion

Cite This Study

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