What question did this study set out to answer?

This research aims to develop a method for synthesizing SCF₃- and SCN-functionalized dihydroisoquinolino[1,2-b]quinazolinones using radical chemistry.

January 23, 2026

Radical Cascade Cyclization of 3-Allyl-2-arylquinazolinones Mediated by Silver(I) Salts to Access SCF₃/SCN-Enriched Dihydroisoquinolino1,2-bquinazolinones

Key Points

This research aims to develop a method for synthesizing SCF₃- and SCN-functionalized dihydroisoquinolino[1,2-b]quinazolinones using radical chemistry.
Utilized silver(I) salts as a mediator in the reaction process.
Employed radical-mediated 1,2-difunctionalization of allylic alkenes.
Followed up with intramolecular cyclization to form polycyclic structures.
Successfully synthesized SCF₃- and SCN-functionalized dihydroisoquinolino compounds.
Demonstrated efficiency in transforming allylic alkenes through a radical pathway.
Achieved enhanced structural complexity in the final products.

Abstract

Herein, we describe an efficient approach for the synthesis of SCF₃-and SCN-functionalized polycyclic Dihydroisoquinolino1,2-bquinazolinones through radical-mediated 1,2-difunctionalization of allylic alkenes followed by intramolecular cyclization. The transformation proceeds through sulfur-radical-triggered C-S...

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Radical Cascade Cyclization of 3-Allyl-2-arylquinazolinones Mediated by Silver(I) Salts to Access SCF₃/SCN-Enriched Dihydroisoquinolino1,2-bquinazolinones

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