Silver-Catalyzed [3 + 2] Cyclization Reaction of α-Azidovinyl Acids with RCF ₂ -Imidoyl Sulfoxonium Ylides: Synthesis of Polyfluoroalkyl-Substituted 2 H -Pyrrole Derivatives

A silver-catalyzed [3 + 2] cyclization of α-azidovinyl acids with RCF₂-imidoyl sulfoxonium ylides has been developed for the first time. This transformation provides an efficient method for constructing polyfluoroalkyl-substituted 2H-pyrroles from readily available precursors with the formation of C-N and C-C bonds in a single step. Further applications, including the synthesis of CF₃-substituted 1H-pyrrole and N-methyl-4-phenyl-N-(p-tolyl)-2-(trifluoromethyl)-2H-pyrrol-2-amine, demonstrated the immense potential and versatility of this cyclization reaction.