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January 24, 20261 citations

Impact and prognostic implications of aortic stenosis across the heart failure spectrum: a cohort study.

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GHGregor HeitzingerCTChristoph-Socrates TorrefrancaSKSophia Koschatko

Key Result

Aortic stenosis significantly worsens long-term outcomes in heart failure patients, highlighting treatment gaps and the need for earlier intervention strategies.

Key Points

  • The study aims to evaluate the impact of aortic stenosis on outcomes and prognosis across various heart failure types.
  • Cohort study design involving patients with heart failure
  • Assessment of mortality risk associated with aortic stenosis
  • Examination of treatment gaps and intervention strategies
  • Aortic stenosis is linked to significantly worse long-term outcomes in heart failure cases
  • High mortality risk persists even with non-severe aortic stenosis
  • Major treatment gaps were identified, indicating a lack of timely interventions

Structured PICO

Does the presence of aortic stenosis worsen long-term outcomes and mortality risk in patients across the heart failure spectrum?

P
Population
Patients across the heart failure (HF) spectrum with aortic stenosis (AS)
I
Intervention
Presence of aortic stenosis (AS), including non-severe stages
O
Outcome
Long-term outcomes and mortality riskhard clinical

Aortic stenosis, even when non-severe, is associated with high mortality across all heart failure subtypes, highlighting a critical treatment gap and the need for trials on earlier intervention.

Abstract

AS is common in HF and is associated with substantially worse long-term outcomes across all HF subtypes, even at non-severe stages. The high mortality risk and frequent lack of intervention highlight major treatment gaps and underscore the need for prospective trials evaluating earlier intervention strategies.

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Cite This Study

Heitzinger et al. (2026) studied this question. Aortic stenosis significantly worsens long-term outcomes in heart failure patients, highlighting treatment gaps and the need for earlier intervention strategies.

synapsesocial.com/papers/69746050bb9d90c67120a2bchttps://doi.org/10.1136/heartjnl-2025-326808
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