October 26, 2017Circulation JournalOpen Access

Acute Heart Failure in Patients With Severe Aortic Stenosis　― Insights From the CURRENT AS Registry ―

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Why the study?

Does acute heart failure at presentation worsen long-term prognosis in patients with severe aortic stenosis?

Structured PICO

Does acute heart failure at presentation worsen long-term prognosis in patients with severe aortic stenosis?

Population

3,813 consecutive patients with severe aortic stenosis from a Japanese multicenter registry, categorized by heart failure status (No HF n=2,210, chronic HF n=813, acute HF n=790).

Intervention

Acute heart failure (defined as hospitalized heart failure at enrolment)

Comparator

No heart failure or chronic heart failure

Outcome

Cumulative 5-year incidence of all-cause death and heart failure hospitalizationhard clinical

Acute heart failure complicating severe aortic stenosis is associated with an extremely poor prognosis that is not fully mitigated by aortic valve replacement.

Discussion

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Implication

May warrant intensified post-AVR surveillance in severe AS; extends evidence on HF phenotypes driving mortality.

Cite This Study

Nagao et al. (2017) studied this question.

synapsesocial.com/papers/6a854cb335bc0eada8d593d1 https://doi.org/10.1253/circj.cj-17-0610

Topics

Heart failure HFrEF treatment Heart failure hospitalization

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Acute Heart Failure in Patients With Severe Aortic Stenosis　― Insights From the CURRENT AS Registry ―

Structured PICO

Discussion

Implication

Cite This Study

Topics

Acute Heart Failure in Patients With Severe Aortic Stenosis　― Insights From the CURRENT AS Registry ―

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider

Acute Heart Failure in Patients With Severe Aortic Stenosis ― Insights From the CURRENT AS Registry ―

Structured PICO

Discussion

Implication

Cite This Study

Topics

Acute Heart Failure in Patients With Severe Aortic Stenosis ― Insights From the CURRENT AS Registry ―

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider

Acute Heart Failure in Patients With Severe Aortic Stenosis　― Insights From the CURRENT AS Registry ―

Acute Heart Failure in Patients With Severe Aortic Stenosis　― Insights From the CURRENT AS Registry ―