Effects of fish oil supplementation on biomarkers of vascular endothelial function in middle-aged and older adults: a randomized controlled trial

Chunxia Quan; Wei Tang; Yuting Qin; Zhang Nian; Zhongxia Li; Limei Mao

doi:10.1039/d5fo04037j

January 1, 2026Food & Function

Effects of fish oil supplementation on biomarkers of vascular endothelial function in middle-aged and older adults: a randomized controlled trial

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Key Points

Evaluate how fish oil supplementation affects biomarkers related to vascular endothelial function in older adults.
Randomized controlled trial design
Participants included middle-aged and older adults
Intervention involved supplementation with fish oil rich in EPA and DHA
Biomarkers measured included ICAM-1 and MCP-1
Fish oil supplementation significantly reduced levels of ICAM-1 and MCP-1
These reductions indicate suppressed endothelial activation
Findings suggest potential cardiovascular prevention benefits of fish oil.

Implication

A randomized controlled trial demonstrates the impact of fish oil on endothelial function biomarkers in older adults, suggesting cardiovascular benefits.

Abstract

EPA/DHA fish oil reduces ICAM-1 & MCP-1, suppressing endothelial activation for cardiovascular prevention in middle-aged/elderly.

Discussion

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Cite This Study

Quan et al. (2026) studied this question.

synapsesocial.com/papers/69746126bb9d90c67120af9f https://doi.org/10.1039/d5fo04037j

View at Publisher

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Effects of fish oil supplementation on biomarkers of vascular endothelial function in middle-aged and older adults: a randomized controlled trial

Key Points

Implication

Abstract

Discussion

Cite This Study

Effects of fish oil supplementation on biomarkers of vascular endothelial function in middle-aged and older adults: a randomized controlled trial

Key Points

Implication

Abstract

Discussion

Cite This Study

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