Key result
Supplementation with approximately 3 g/d of EPA or DHA for 6 weeks did not significantly alter platelet-monocyte aggregation compared to placebo in healthy young men.
Why the study?
Does EPA or DHA supplementation reduce platelet-monocyte aggregates and improve vascular function in healthy young men?
Population
49 healthy young men. Exclusion criteria: history of CVD, diabetes, cancer, kidney, liver or bowel disease…
Comparison
EPA-rich or DHA-rich triglyceride concentrates… vs Refined olive oil 5 g/d in soft gel capsules for…
Design
RCT, Randomly allocated using a parallel design, Single-blind…
Follow-up
6 weeks
Authors
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No effect on platelet-monocyte aggregates or vascular function in healthy young men; leaves open differential benefits in higher-risk populations.
RCT (n=48)
Single-blind
Randomized
No
Does EPA or DHA supplementation reduce platelet-monocyte aggregates and improve vascular function in healthy young men?
Absolute Event Rate: 0.4% vs -0.5%
p-value: p=0.382
Supplementation with EPA or DHA for 6 weeks does not significantly alter platelet-monocyte aggregation or vascular function in healthy young men.
Cottin et al. (2016) conducted an RCT in Healthy (n=48). EPA-rich or DHA-rich triglyceride concentrates vs. Refined olive oil (placebo) was evaluated on Change in platelet monocyte aggregates (PMA) (p=0.382). Supplementation with approximately 3 g/d of EPA or DHA for 6 weeks did not significantly alter platelet-monocyte aggregation compared to placebo in healthy young men.
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