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This review aims to synthesize evidence on neurobiological mechanisms and psychological effects of sensory deprivation.

January 25, 2026Brain SciencesOpen Access

Sensory Deprivation and the Brain: Neurobiological Mechanisms, Psychological Effects, and Clinical Implications

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Narrative review synthesizes effects of sensory deprivation on brain function and mental health, highlighting clinical relevance.

This review aims to synthesize evidence on neurobiological mechanisms and psychological effects of sensory deprivation.
Conducted a narrative literature search in PubMed, Scopus, and PsycINFO.
Included studies on biological, cognitive, and psychological effects of reduced sensory input.
Thematically synthesized data without quantitative meta-analysis.
Sensory deprivation induces adaptations in neurotransmitter systems and dysregulates the HPA axis.
Increased risk of depression, anxiety, cognitive impairment, and hallucinations noted.
Short-term, voluntary sensory restriction may enhance relaxation and emotional regulation.

Marazziti et al. (2026) studied this question.

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