Outcomes of Left Atrial Appendage Occlusion in Patients With Hypertrophic Cardiomyopathy, Rheumatic Heart Disease, and Cardiac Amyloidosis.

Mohamad S. Alabdaljabar; Abdullah Al‐Abcha; Mohamad Alkhouli; Benjamin Hibbert; Xiaoke Ken Liu; Trevor Simard; H. Van Houten; Xiaoxi Yao; Freddy Del-Carpio Munoz; Rowlens M. Melduni; Peter A Noseworthy; David Rushlow; P. Kerim Friedman; Ammar M Killu

doi:10.1016/j.jacep.2025.12.019

January 21, 2026

Outcomes of Left Atrial Appendage Occlusion in Patients With Hypertrophic Cardiomyopathy, Rheumatic Heart Disease, and Cardiac Amyloidosis.

View at Publisher

Ask AI

Bookmark

Share

Key result

Patients with atrial fibrillation and rheumatic heart disease had higher bleeding rates after LAAO, but similar stroke/TIA rates compared to those without these conditions.

Why the study?

Does left atrial appendage occlusion (LAAO) have different bleeding and stroke/TIA outcomes in AF patients with HCM, RHD, or CA compared to those without these conditions?

Key Points

The study aims to investigate the outcomes of left atrial appendage occlusion in patients with various heart diseases.
Compared bleeding rates post-LAAO in patients with AF and specific heart conditions.
Analyzed outcomes in cohorts of patients with hypertrophic cardiomyopathy, rheumatic heart disease, and cardiac amyloidosis.
Examined stroke and TIA rates among these groups.
Patients with AF and rheumatic heart disease or cardiac amyloidosis had higher bleeding rates post-LAAO.
No differences in outcomes were observed between AF patients with and without hypertrophic cardiomyopathy.
Findings in HCM and cardiac amyloidosis groups are primarily hypothesis generating due to small sample sizes.

Structured PICO

Does left atrial appendage occlusion (LAAO) have different bleeding and stroke/TIA outcomes in AF patients with HCM, RHD, or CA compared to those without these conditions?

P

Population

Patients with atrial fibrillation (AF) and either hypertrophic cardiomyopathy (HCM), rheumatic heart disease (RHD), or cardiac amyloidosis (CA).

I

Intervention

Left atrial appendage occlusion (LAAO)

C

Comparator

Patients with AF undergoing LAAO without HCM, RHD, or CA

O

Outcome

Bleeding rates and stroke/TIA rateshard clinical

Limitations

Small sample size in HCM and CA cohorts, making results mainly hypothesis generating

Implication

LAAO in AF patients with RHD or CA is associated with higher bleeding risk compared to those without these conditions, though stroke/TIA rates remain similar in the RHD cohort.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Alabdaljabar et al. (2026) studied this question. Patients with atrial fibrillation and rheumatic heart disease had higher bleeding rates after LAAO, but similar stroke/TIA rates compared to those without these conditions.

synapsesocial.com/papers/6975b229feba4585c2d6db5a https://doi.org/10.1016/j.jacep.2025.12.019