B-36 | In-Hospital Outcomes of Percutaneous Left Atrial Appendage Closure in Patients With Hypertrophic Cardiomyopathy: An Insight From National Inpatient Sample Data

Atrial fibrillation (AFib) is a common arrhythmia in patients with hypertrophic cardiomyopathy (HCM), associated with a high risk of embolic stroke regardless of CHA2DS2-VASc score. In-hospital outcomes of patients with HCM with AFib undergoing left atrial appendage occlusion (LAAO) are unknown. We used National Inpatient Sample (NIS) data from 2016 to 2019 for our analysis. Linear and logistic regression analyses were used to evaluate continuous and binary outcomes, respectively. Outcomes were adjusted for age, sex, and Elixhauser Comorbidity Index. We evaluated 60,607 hospitalized patients from 2016 to 2019 who underwent a LAAO procedure. Patients with HCM (n= 386) were younger than patients without HCM (60,221) (72 vs 76 years, p<0.01). Females made up 42% of both groups. The in-hospital mortality rate was 0.7% in the HCM group and 0.1% in the non-HCM group. HCM was associated with higher in-hospital mortality on both univariate (OR 6.87, CI 1.629 - 29.01, p=0.009) and multivariate analysis (adjusted OR 7, CI 1.64 - 30.29, p=0.009), as shown in Table 1. However, HCM was not independently associated with an increase in the length of stay (adjusted β=.0.009, CI -0.271 - 0.290, p=0.947) or total hospital cost (adjusted β=2154, CI -1100 - 5409, p=0.195). HCM is independently associated with an increased risk of in-hospital mortality in patients who undergo percutaneous LAAO. It is important to investigate the underlying factors for increased mortality in patients with HCM undergoing percutaneous LAAO.