What question did this study set out to answer?

This review aims to evaluate the laboratory diagnostic methods used in diagnosing pyrexia of unknown origin (PUO).

Laboratory Diagnosis of Pyrexia of Unknown Origin: A Narrative Review

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Narrative review evaluates laboratory diagnostic methods for Pyrexia of Unknown Origin, suggesting improved techniques for better outcomes.

This review aims to evaluate the laboratory diagnostic methods used in diagnosing pyrexia of unknown origin (PUO).
Conducted a literature search on databases like PubMed and Scopus.
Included studies published since 2014 focusing on laboratory diagnosis of PUO.
Extracted data on study design, sample size, and diagnostic techniques.
Traditional methods like blood cultures showed 20%-30% positivity in PUO cases.
Serological tests helped identify infections but had issues with cross-reactivity.
Molecular diagnostics like PCR and next-generation sequencing improved pathogen identification quickly.

Sivasangeetha et al. (2026) studied this question.

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Narrative review evaluates laboratory diagnostic methods for Pyrexia of Unknown Origin, suggesting improved techniques for better outcomes.