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January 26, 2026F1000ResearchOpen Access

Bioactive Effects of Plectranthus amboinicus Extract Using Microwave Techniques and Its Value Addition in Cosmeceutical Products

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Investigates bioactive effects of Plectranthus amboinicus extract in cosmetic formulations, indicating its multifunctional potential.

This research aims to explore the bioactive effects of Plectranthus amboinicus extract for use in skincare products.
Utilized microwave-assisted ethanol extraction for bioactive compounds.
Compared tray drying and freeze-drying methods to assess extraction efficiency.
Evaluated bioactive content through caffeic acid quantification and antioxidant activity tests.
Assessed antimicrobial activity against various skin pathogens.
Tested anti-inflammatory effects using LPS-stimulated THP-1 macrophages.
The PF15 extract showed the highest bioactive compound levels and strong antioxidant activity.
Demonstrated significant antimicrobial effects against Staphylococcus aureus, Staphylococcus epidermidis, and Cutibacterium acnes.
PF15 extract reduced pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and increased anti-inflammatory IL-10.
The formulated cream remained stable throughout six heat-cool cycles with no adverse changes.

Chinnahong et al. (2026) studied this question.

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