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January 26, 2026Analytical Chemistry

Single-Molecule Analysis of Glycopeptide Antibiotic–Target Interactions Using Nanopore-Based Biomimetic Probes

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Authors

ZSZhuoqun SuShaanxi University of Science and TechnologyYZYan ZhaoShaanxi University of Science and TechnologyLJLiuxin JiaoShaanxi University of Science and Technology

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Implication

Demonstrates real-time analysis of glycopeptide interactions in bacteria, suggesting insights for overcoming antibiotic resistance.

Key Points

  • The research aims to understand the interactions between glycopeptide antibiotics and their bacterial targets at the single-molecule level.
  • Utilized nanopore-based biomimetic probes to study glycopeptide-peptidoglycan interactions.
  • Designed biomimetic peptidoglycan precursor peptides (BPGPPs) for experimentation.
  • Performed real-time single-molecule recordings using the α-hemolysin nanopore.
  • Achieved real-time recordings of BPGPP-glycopeptide complex dissociation.
  • Measured binding affinities based on mean dwell times of complexes within the nanopore.
  • Investigated terminal residue mutations to reveal insights into resistance mechanisms.

Cite This Study

Su et al. (2026) studied this question.

synapsesocial.com/papers/697703f6722626c4468e9029https://doi.org/10.1021/acs.analchem.5c07349
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