Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort ― Results From Kochi RYOMA Study ―
Key result
Unselected Japanese HCM patients demonstrate a ~94% five-year HCM-related survival rate.
- n=293
Population
293 patients with hypertrophic cardiomyopathy in a regional Japanese cohort, mean age 63±14 years, 67% male.
Design
Cohort
Follow-up
mean 6.1±3.2 years
Authors
Discussion
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Implication
Favorable survival but 20% event rate in aged Japanese HCM cohort; extends observational data on predictors and leaves open targeted interventions.
Study Design
Type
Cohort (n=293)
Multicenter
Yes
Structured PICO
P
Population
293 patients with hypertrophic cardiomyopathy (HCM) in a regional Japanese cohort (Kochi Prefecture), mean age 63±14 years, 67% male.
O
Outcome
HCM-related deaths (sudden death, HF-related death, stroke-related death) and HCM-related adverse cardiovascular events (composite of HCM-related death, hospitalization for HF, embolic stroke admission, spontaneous sustained VT with hemodynamic instability, or appropriate ICD discharge)composite
In an aged Japanese community cohort, HCM mortality was favorable but 20% of patients experienced HCM-related adverse cardiovascular events within 5 years, with NYHA class III, AF, lower fractional shortening, and LVOTO being significant predictors.
Limitations
- Relatively small number of HCM-related events, especially deaths; Holter monitoring was not performed in all patients at registration.
- The number of HCM-related events, particularly HCM-related deaths, was relatively small and some of the statistical analyses might have been affected
- Holter monitoring should have been performed in all patients at registration
Cite This Study
Kubo et al. (2018) conducted a cohort in Hypertrophic Cardiomyopathy (n=293). HCM-related 5-year survival rate was 94% and HCM-related 5-year event-free rate was 80% in an unselected cohort of Japanese patients with hypertrophic cardiomyopathy.