What question did this study set out to answer?

This research examines the relationship between abnormal papillary muscle morphology and left ventricular outflow tract obstruction in hypertrophic cardiomyopathy patients.

August 9, 2007Heart

Abnormal papillary muscle morphology is independently associated with increased left ventricular outflow tract obstruction in hypertrophic cardiomyopathy

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Key result

Abnormal papillary muscle morphology is associated with increased resting left ventricular outflow tract gradient in patients with hypertrophic cardiomyopathy, independent of septal thickness.

Why the study?

Is abnormal papillary muscle morphology associated with increased resting LVOT gradient in patients with HCM?

Population

Patients with hypertrophic cardiomyopathy (HCM)

Design

Cross-sectional

Authors

DKDeborah KwonCardiac Imaging RSRandolph M. SetserSiemens Healthcare (United States)MTMaran ThamilarasanCardiac Imaging

Discussion

Member takes

Implication

Supports papillary muscle assessment in HCM evaluation; hypothesis-generating for morphology-targeted therapies before practice change.

Key Points

This research examines the relationship between abnormal papillary muscle morphology and left ventricular outflow tract obstruction in hypertrophic cardiomyopathy patients.
Patients with hypertrophic cardiomyopathy were assessed for papillary muscle morphology and resting left ventricular outflow tract gradient.
Septal thickness was measured and analyzed to determine its relationship with the LVOT gradient.
Patients with abnormal papillary muscles exhibited a higher resting left ventricular outflow tract gradient than those with normal morphology.
The association between abnormal papillary muscle morphology and increased LVOT gradient remained significant after adjusting for septal thickness.

Structured PICO

Is abnormal papillary muscle morphology associated with increased resting LVOT gradient in patients with HCM?

Population

Patients with hypertrophic cardiomyopathy (HCM)

Intervention

Abnormal papillary muscle (PM) morphology

Outcome

Resting left ventricular outflow tract (LVOT) gradientsurrogate

Abnormal papillary muscle morphology is an independent contributor to resting LVOT obstruction in hypertrophic cardiomyopathy, regardless of septal thickness.

Cite This Study

Kwon et al. (2007) studied this question. Abnormal papillary muscle morphology is associated with increased resting left ventricular outflow tract gradient in patients with hypertrophic cardiomyopathy, independent of septal thickness.

synapsesocial.com/papers/6978067bb4f402aaa34cc65f https://doi.org/10.1136/hrt.2007.118018

Topics

Cardiomyopathy Hypertrophic cardiomyopathy Echocardiography

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Abnormal papillary muscle morphology is independently associated with increased left ventricular outflow tract obstruction in hypertrophic cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Abnormal papillary muscle morphology is independently associated with increased left ventricular outflow tract obstruction in hypertrophic cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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