What question did this study set out to answer?

This study aims to assess the diagnostic value of routine laboratory tests in identifying Gram-negative bacterial causes of neonatal sepsis.

January 27, 2026Scripta MedicaOpen Access

Utility of routine laboratory tests for predicting Gram-negative neonatal sepsis in low-resource settings

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Authors

NANabeeha N AkramMustansiriyah University SASabah M. AliMinistry of Education Science and Technology RRRasha Raheem

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Implication

This retrospective study evaluates the effectiveness of routine lab tests in predicting Gram-negative sepsis in neonates, suggesting practical diagnostic approaches for low-resource settings.

Key Points

This study aims to assess the diagnostic value of routine laboratory tests in identifying Gram-negative bacterial causes of neonatal sepsis.
Retrospective study of neonates with culture-proven early-onset neonatal sepsis at a tertiary hospital in Iraq.
Participants categorized into those with Gram-negative sepsis and those with positive bacterial cultures.
Clinical characteristics and lab results, including C-reactive protein and complete blood count parameters, compared between groups.
Receiver operating characteristic curve analysis was conducted to evaluate test predictive values.
Among 80 neonates, 64 (80%) had Gram-negative bacterial isolates, predominantly Acinetobacter baumannii (38.8%).
C-reactive protein levels were significantly higher in neonates with Gram-negative sepsis (p = 0.003).
Absolute neutrophil count and N:L ratio were higher in Gram-positive cases (p = 0.03, p = 0.04).
CRP showed a strong association with Gram-negative sepsis; a CRP cutoff of 19.53 mg/dL indicated an excellent prediction with an AUC of 0.933 (95% CI: 0.807-1.000; p = 0.009).

Cite This Study

Akram et al. (2025) studied this question.

synapsesocial.com/papers/697854fdccb046adae517342 https://doi.org/10.5937/scriptamed56-62030

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Implication

This retrospective study evaluates the effectiveness of routine lab tests in predicting Gram-negative sepsis in neonates, suggesting practical diagnostic approaches for low-resource settings.

Utility of routine laboratory tests for predicting Gram-negative neonatal sepsis in low-resource settings

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Member takes

Implication

Key Points

Cite This Study

Utility of routine laboratory tests for predicting Gram-negative neonatal sepsis in low-resource settings

Discussion

Member takes

Implication

Key Points

Cite This Study

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