Key result
Rising noncardiovascular events offset overall mortality improvements in young and middle-aged HF patients.
While cardiovascular mortality in incident heart failure has decreased, overall mortality improvements are offset by increasing noncardiovascular events, highlighting the need for comorbidity management and infection prevention.
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Non-CV mortality offsets CV gains in young/middle-aged HF; challenges prior improvement consensus and leaves open targeted comorbidity trials.
Among patients with a new heart failure diagnosis, considerable progress has been achieved in reducing mortality in young and middle-aged patients and cardiovascular mortality across all age groups. Improvements to overall mortality are hindered by high and increasing rates of noncardiovascular events. These findings challenge current research priorities and management strategies and call for a greater emphasis on associated comorbidities. Specifically, infection prevention presents as a major opportunity to improve prognosis.
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Conrad et al. (2019) studied this question. Mortality rates have improved in young and middle-aged heart failure patients, but increasing noncardiovascular event rates hinder overall mortality reductions.
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