Key result
Higher plasma tHcy is associated with ~0.8 m/s greater cf-PWV in hypertensive patients.
Why the study?
Is elevated plasma total homocysteine associated with increased aortic arterial stiffness and wave reflection in hypertensive and normotensive subjects?
Cross-Sectional (n=1,680)
No
Is elevated plasma total homocysteine associated with increased aortic arterial stiffness and wave reflection in hypertensive and normotensive subjects?
Answers are grounded in this paper and cite their sources.
Elevated plasma homocysteine is independently associated with increased aortic arterial stiffness in hypertensive patients, suggesting hypertension is a major link between homocysteine and vascular damage.
Plasma tHcy level is strongly and independently correlated with arterial stiffness measured as cf-PWV only in hypertensive subjects. Thus, hypertension is a major link between tHcy and aortic arterial stiffness.
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Xiao et al. (2014) conducted a cross-sectional in Hypertension (n=1,680). Plasma total homocysteine (tHcy) vs. Healthy control or lower tHcy levels was evaluated on Association between plasma tHcy levels and carotid-femoral pulse wave velocity (cf-PWV) in hypertensive subjects (b = 0.713, p=0.004). Plasma tHcy level is independently associated with increased carotid-femoral pulse wave velocity (cf-PWV) of 13.12 m/s in hypertensive subjects versus 12.34 m/s in those with lower tHcy levels (p = 0.004).
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