Plasma Homocysteine, Aortic Stiffness, and Renal Function in Hypertensive Patients
Why the study?
Is plasma homocysteine associated with aortic stiffness and clinical vascular disease in hypertensive patients?
Population
236 hypertensive patients
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May support vascular risk assessment in hypertension; leaves open causal role and need for interventional trials.
Structured PICO
Is plasma homocysteine associated with aortic stiffness and clinical vascular disease in hypertensive patients?
P
Population
236 hypertensive patients
O
Outcome
Arterial stiffness measured by carotid-femoral pulse wave velocitysurrogate
In hypertensive patients, plasma homocysteine levels are independently correlated with aortic stiffness and are higher in those with clinical vascular disease, suggesting its utility in cardiovascular risk assessment.
Cite This Study
Bortolotto et al. (1999) studied this question.