Associations of Plasma Natriuretic Peptide, Adrenomedullin, and Homocysteine Levels With Alterations in Arterial Stiffness
Why the study?
Are plasma natriuretic peptide, adrenomedullin, and homocysteine levels associated with arterial stiffness in a community-based cohort?
Population
1962 participants in the Framingham Heart Study, mean age 61 years, 56% women.
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Sex-specific associations are hypothesis-generating; prospective studies needed before any clinical consideration.
Structured PICO
Are plasma natriuretic peptide, adrenomedullin, and homocysteine levels associated with arterial stiffness in a community-based cohort?
P
Population
1962 participants in the Framingham Heart Study, mean age 61 years, 56% women.
I
Intervention
Plasma N-terminal atrial natriuretic peptide, B-type natriuretic peptide, adrenomedullin, and homocysteine concentrations
O
Outcome
Arterial stiffness assessed by tonometry (central pulse pressure, forward pressure wave, reflected pressure wave, carotid-femoral pulse wave velocity, and carotid-radial pulse wave velocity)surrogate
Plasma natriuretic peptide, adrenomedullin, and homocysteine levels are associated with sex-specific alterations in arterial stiffness in a community cohort.
Cite This Study
Levy et al. (2007) studied this question.