Key result
Beta(1)-adrenergic receptor polymorphisms are important determinants of the diastolic blood pressure response to metoprolol in hypertensive patients.
Why the study?
Do beta1-adrenergic receptor polymorphisms predict the antihypertensive response to metoprolol in patients with hypertension?
Do beta1-adrenergic receptor polymorphisms predict the antihypertensive response to metoprolol in patients with hypertension?
Beta1-adrenergic receptor polymorphisms at codons 49 and 389 may help predict diastolic blood pressure response to metoprolol in hypertensive patients.
May inform metoprolol response prediction via beta1-AR genotyping in hypertension; leaves open prospective validation before practice change.
Our data suggest that beta(1)-adrenergic receptor polymorphisms are important determinants of antihypertensive response to metoprolol. In the future, codon 49 and 389 genotypes or beta(1)-adrenergic receptor haplotypes might be used to predict the diastolic blood pressure response to metoprolol in patients with hypertension.
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J JOHNSON (2003) studied this question. Beta(1)-adrenergic receptor polymorphisms are important determinants of the diastolic blood pressure response to metoprolol in hypertensive patients.
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