What question did this study set out to answer?

This study investigates whether 68Ga-DOTANOC PET/CT provides comparable diagnostic performance for cardiac sarcoidosis to 18F-FDG PET/CT and cardiac MRI.

February 2, 2026Nuclear Medicine Communications

Diagnostic performance of 68Ga-DOTANOC PET/computed tomography in cardiac sarcoidosis: comparison with 18F-fluorodeoxyglucose PET/computed tomography and cardiac magnetic resonance

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This study investigates whether 68Ga-DOTANOC PET/CT provides comparable diagnostic performance for cardiac sarcoidosis to 18F-FDG PET/CT and cardiac MRI.
Enrolled 23 patients with confirmed sarcoidosis or cardiac abnormalities.
Conducted cardiac MRI, 18F-FDG PET/CT after dietary modifications, and 68Ga-DOTANOC PET/CT.
Analyzed intermodality agreement using Cohen’s κ for both patient-wise and segment-wise assessments.
68Ga-DOTANOC and cardiac MRI demonstrated almost perfect segment-wise agreement (Cohen’s κ: 0.88).
18F-FDG PET/CT and cardiac MRI also exhibited strong segment-wise agreement (Cohen’s κ: 0.80).
Mean lesion standardized uptake values and target-to-background ratios were similar between 68Ga-DOTANOC and 18F-FDG.

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Implication

Prospective study compares diagnostic capabilities of 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT in cardiac sarcoidosis, suggesting its potential use.

Cite This Study

Solanki et al. (2026) studied this question.

synapsesocial.com/papers/6980fbbec1c9540dea80d8a6 https://doi.org/10.1097/mnm.0000000000002113

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Implication

Prospective study compares diagnostic capabilities of 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT in cardiac sarcoidosis, suggesting its potential use.

Diagnostic performance of 68Ga-DOTANOC PET/computed tomography in cardiac sarcoidosis: comparison with 18F-fluorodeoxyglucose PET/computed tomography and cardiac magnetic resonance

Key Points

Discussion

Implication

Cite This Study

Diagnostic performance of 68Ga-DOTANOC PET/computed tomography in cardiac sarcoidosis: comparison with 18F-fluorodeoxyglucose PET/computed tomography and cardiac magnetic resonance

Key Points

Discussion

Implication

Cite This Study

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