What question did this study set out to answer?

This study evaluates the effectiveness of tenecteplase compared to alteplase in achieving better outcomes for patients with large vessel occlusion during thrombectomy.

February 2, 2026Stroke

Abstract DP027: Alteplase to Tenecteplase: Large Vessel Occlusion Outcomes at a Single Comprehensive Stroke Center

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This study evaluates the effectiveness of tenecteplase compared to alteplase in achieving better outcomes for patients with large vessel occlusion during thrombectomy.
Prospective data collection of acute ischemic stroke patients with large vessel occlusion.
Cohorts divided into alteplase and tenecteplase groups based on treatment timelines.
Data analyzed included TICI reperfusion scores and outcomes of mechanical endovascular reperfusion.
In the tenecteplase group, 67% of potential thrombectomies were aborted due to neurologic improvement versus none in the alteplase group (p=0.13).
The tenecteplase group had a higher rate of greater than TICI 2b outcomes (92%) compared to alteplase (50%), though not statistically significant (p=0.08).

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Implication

A single center evaluation shows tenecteplase may improve reperfusion rates in patients with large vessel occlusion, suggesting potential benefits.

Cite This Study

Tremain et al. (2026) studied this question.

synapsesocial.com/papers/6980fcb6c1c9540dea80e780 https://doi.org/10.1161/str.57.suppl_1.dp027

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Implication

A single center evaluation shows tenecteplase may improve reperfusion rates in patients with large vessel occlusion, suggesting potential benefits.

Abstract DP027: Alteplase to Tenecteplase: Large Vessel Occlusion Outcomes at a Single Comprehensive Stroke Center

Key Points

Discussion

Implication

Cite This Study

Abstract DP027: Alteplase to Tenecteplase: Large Vessel Occlusion Outcomes at a Single Comprehensive Stroke Center

Key Points

Discussion

Implication

Cite This Study

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