What question did this study set out to answer?

This research aims to compare the safety and efficacy of intravenous tenecteplase and alteplase in acute ischemic stroke patients undergoing mechanical thrombectomy.

February 2, 2026Stroke

Abstract TP011: Outcomes of acute ischemic stroke patients receiving IV tenecteplase versus IV alteplase with and without thrombectomy in real world setting

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This research aims to compare the safety and efficacy of intravenous tenecteplase and alteplase in acute ischemic stroke patients undergoing mechanical thrombectomy.
Analyzed data from 270 acute ischemic stroke patients treated with IV thrombolysis between 10/2020 and 03/2023.
Examined safety outcomes like intracranial hemorrhage and neurological improvements.
Stratified data based on whether patients received mechanical thrombectomy or not.
Performed multivariate analyses to assess risks associated with treatments.
Higher incidence of new intracranial hemorrhage in TNK patients (44.2%) compared to tPA patients (20%), p=0.015.
Symptomatic intracerebral hemorrhage was higher in TNK (16.3%) than tPA (4.4%), p=0.067.
TNK and thrombectomy were linked to a significantly higher risk of any intracranial hemorrhage (aOR 3.69, p=0.020).
Non-routine discharges were more common in TNK-treated patients (aOR 7.24, p=0.002).
TNK treatment showed a marginal association with major neurological improvement at 24 hours (aOR 1.96, p=0.255).

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Implication

Real-world comparisons reveal risks of intracranial hemorrhage in acute ischemic stroke patients receiving thrombolytics and thrombectomy.

Cite This Study

Sahito et al. (2026) studied this question.

synapsesocial.com/papers/6980fd9dc1c9540dea80f5ea https://doi.org/10.1161/str.57.suppl_1.tp011

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Implication

Real-world comparisons reveal risks of intracranial hemorrhage in acute ischemic stroke patients receiving thrombolytics and thrombectomy.

Abstract TP011: Outcomes of acute ischemic stroke patients receiving IV tenecteplase versus IV alteplase with and without thrombectomy in real world setting

Key Points

Discussion

Implication

Cite This Study

Abstract TP011: Outcomes of acute ischemic stroke patients receiving IV tenecteplase versus IV alteplase with and without thrombectomy in real world setting

Key Points

Discussion

Implication

Cite This Study

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