What question did this study set out to answer?

The study aims to assess the reproducibility of complications from TNK versus tPA in acute ischemic stroke.

February 2, 2026Stroke

Abstract WP056: Safety of Tenecteplase v Alteplase in Telestroke: Assessment for Reproducibility (STAT 2.0)

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The study aims to assess the reproducibility of complications from TNK versus tPA in acute ischemic stroke.
Extracted data from the TeleSpecialists TeleStroke Registry™ for acute ischemic stroke consults.
Reviewed encounters for intravenous thrombolytic candidates and treatment details.
Analyzed door to needle times and complications with statistical tests.
6450 patients analyzed, with faster door to needle times for TNK (41 min vs. 42 min).
Overall complication rates were higher in TNK group but not statistically significant.
Significant increase in intracerebral hemorrhage rates in the TNK group (1.92% vs. 1.02%).

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Multicenter study compares complication rates of TNK and tPA, highlighting significant ICH risk.

Figurelle et al. (2026) studied this question.

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