What question did this study set out to answer?

The study aims to investigate complication rates associated with tenecteplase in various stroke center types.

February 2, 2026Stroke

Abstract TP040: Tenecteplase-Associated Complications: A Retrospective Analysis Across a Regional Stroke System

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The study aims to investigate complication rates associated with tenecteplase in various stroke center types.
Conducted a retrospective multicenter study across 19 hospitals.
Analyzed complications such as symptomatic ICH and angioedema occurring within 36 hours of tenecteplase administration.
Utilized data from Epic and the American Heart Association’s Get with the Guidelines registry.
Compared complication rates using Fisher's exact test.
Of 554 tenecteplase administrations, 16 complications occurred (2.9% overall complication rate).
The rates of symptomatic intracranial hemorrhage were 13 cases, and 3 cases of angioedema.
Complication rates were not statistically significant among different hospital types (p=0.051).

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Retrospective analysis explores post-tenecteplase complication rates in regional stroke centers, suggesting consistent safety profiles.

Graves et al. (2026) studied this question.

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