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February 2, 2026Stroke

Abstract WP028: Efficacy and Safety of Tenecteplase versus Alteplase Across Different Treatment Time Windows: A Monocentric One-Year Stroke Center Experience

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To compare efficacy and safety outcomes of tenecteplase and alteplase in acute ischemic stroke treatment across different time windows.
Retrospective analysis of a stroke registry over one year before and after the transition from alteplase to tenecteplase.
Included all patients treated with intravenous thrombolysis within conventional (≤4.5h) and extended (>4.5h) treatment windows.
Evaluated primary endpoints such as door-to-needle times and safety endpoints including intracranial hemorrhage.
Total of 591 patients treated with intravenous thrombolysis, with faster door-to-needle times for tenecteplase (31 min vs. 35 min; p=0.002).
Reduction in imaging-to-needle times with tenecteplase (12 min vs. 16 min; p<0.001).
No significant differences in safety outcomes between tenecteplase and alteplase for overall or symptomatic intracranial hemorrhage.

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Implication

This one-year cohort study compares efficacy and safety of tenecteplase and alteplase in acute ischemic stroke care, suggesting tenecteplase as a preferred option.

Cite This Study

Sekita et al. (2026) studied this question.

synapsesocial.com/papers/6980fd60c1c9540dea80f112 https://doi.org/10.1161/str.57.suppl_1.wp028

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Implication

This one-year cohort study compares efficacy and safety of tenecteplase and alteplase in acute ischemic stroke care, suggesting tenecteplase as a preferred option.

Abstract WP028: Efficacy and Safety of Tenecteplase versus Alteplase Across Different Treatment Time Windows: A Monocentric One-Year Stroke Center Experience

Key Points

Discussion

Implication

Cite This Study

Abstract WP028: Efficacy and Safety of Tenecteplase versus Alteplase Across Different Treatment Time Windows: A Monocentric One-Year Stroke Center Experience

Key Points

Discussion

Implication

Cite This Study

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