What does this research mean for the field?

Transitioning from alteplase to tenecteplase for acute ischemic stroke significantly reduces door-to-needle times and improves workflow efficiency while maintaining comparable safety across standard, extended, and off-label treatment windows. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to compare the treatment efficiency and safety of tenecteplase and alteplase in acute ischemic stroke.

May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a894 Efficiency and Safety of Tenecteplase Versus Alteplase Across Different Treatment Time Windows: A Monocentric One-Year Stroke Center Experience

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Authors

ASAlexander SekitaFriedrich-Alexander-Universität Erlangen-Nürnberg KMKosmas MachaFriedrich-Alexander-Universität Erlangen-Nürnberg LSLudwig SingerFriedrich-Alexander-Universität Erlangen-Nürnberg

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Implication

Randomized trial compares efficiency and safety of tenecteplase to alteplase in acute ischemic stroke, indicating improved workflow.

Key Points

This research aims to compare the treatment efficiency and safety of tenecteplase and alteplase in acute ischemic stroke.
Retrospective analysis of AIS patients treated with IVT in a one-year stroke registry.
Transition from alteplase to tenecteplase for IVT in June 2024.
Primary endpoints included in-hospital workflow times, while safety endpoints assessed intracranial hemorrhage.
Tenecteplase showed shorter door-to-needle (31 min vs. 35 min, p=0.002) and imaging-to-needle times (12 min vs. 16 min, p<0.001) compared to alteplase.
Safety outcomes were similar, with no significant difference in any intracranial hemorrhage (8% vs. 7%, p=0.61) or symptomatic ICH (3% vs. 1%, p=0.34).
No increase in hemorrhagic complications noted in off-label scenarios.

Cite This Study

Sekita et al. (2026) studied this question.

synapsesocial.com/papers/69fd7fcdbfa21ec5bbf08587 https://doi.org/10.1093/esj/aakag023.472

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Abstract Number: Esoc2026a894 Efficiency and Safety of Tenecteplase Versus Alteplase Across Different Treatment Time Windows: A Monocentric One-Year Stroke Center Experience

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Cite This Study

Abstract Number: Esoc2026a894 Efficiency and Safety of Tenecteplase Versus Alteplase Across Different Treatment Time Windows: A Monocentric One-Year Stroke Center Experience

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Cite This Study

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