What question did this study set out to answer?

This analysis aims to compare treatment times and safety outcomes of tenecteplase versus alteplase in acute ischemic stroke patients.

February 2, 2026Stroke

Abstract DP301: Alteplase vs. Tenecteplase: Comparison of Treatment Times and Hemorrhagic Complications in a large US health care system

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Authors

JTJason TarpleyLittle Company of Mary Hospital HMHoria MargineanAllen Institute for Brain Science TSTamela StuchinerProvidence College

Discussion

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Implication

Retrospective analysis demonstrates better treatment times and safety outcomes for tenecteplase in ischemic stroke, indicating its advantages over alteplase.

Key Points

This analysis aims to compare treatment times and safety outcomes of tenecteplase versus alteplase in acute ischemic stroke patients.
Retrospective analysis of adult acute ischemic stroke patients from a large US health care system.
Comparison of door-to-needle time (DTN) and door-to-device time (DTD).
Assessment of safety outcomes, including symptomatic intracerebral hemorrhage (sICH) and life-threatening hemorrhage (ltHEM).
Median DTN for the TNK group was significantly shorter at 35 minutes compared to alteplase.
Median DTD for TNK was 103 minutes, showcasing improved timing.
TNK treatment showed a lower likelihood of sICH events compared to alteplase, with statistical significance.

Cite This Study

Tarpley et al. (2026) studied this question.

synapsesocial.com/papers/6980fc17c1c9540dea80de3c https://doi.org/10.1161/str.57.suppl_1.dp301

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Implication

Retrospective analysis demonstrates better treatment times and safety outcomes for tenecteplase in ischemic stroke, indicating its advantages over alteplase.

Abstract DP301: Alteplase vs. Tenecteplase: Comparison of Treatment Times and Hemorrhagic Complications in a large US health care system

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract DP301: Alteplase vs. Tenecteplase: Comparison of Treatment Times and Hemorrhagic Complications in a large US health care system

Discussion

Member takes

Implication

Key Points

Cite This Study

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