What question did this study set out to answer?

The study aimed to compare the efficacy and safety of rTPA versus TNK for treating acute ischemic stroke.

Abstract Number: Esoc2026a1511 Hyperacute Outcomes of Intravenous Thrombolysis: Rtpa Versus Tenecteplase (Tnk)

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Retrospective study compares efficacy and safety of rTPA and TNK in acute ischemic stroke, suggesting workflow advantages for TNK.

The study aimed to compare the efficacy and safety of rTPA versus TNK for treating acute ischemic stroke.
Retrospective observational study of patients with acute ischemic stroke treated with thrombolysis from January 2024 to December 2025.
Primary efficacy outcomes included NIHSS scores at 24 hours, early neurological improvement, and averted recanalization.
Primary safety outcomes were symptomatic intracerebral hemorrhage and in-hospital mortality.
92 patients included, with 44 receiving rTPA and 48 receiving TNK.
TNK showed significantly shorter median door-to-imaging, door-to-needle, and door-to-groin times.
sICH occurred more frequently in the TNK group at 14.6% compared to 0% in the rTPA group (p < 0.05).

Rosales et al. (2026) studied this question.

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