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February 2, 2026Stroke

Abstract TP056: Effectiveness and Safety of Tenecteplase in Patients with Large Vessel Occlusion Not Undergoing Thrombectomy: A Retrospective Cohort Study

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To evaluate the effectiveness and safety of tenecteplase in patients with large vessel occlusion not undergoing thrombectomy.
Retrospective review of 391 patients treated with tenecteplase from January 2022 to January 2024
74 patients had large vessel occlusion stroke not treated with thrombectomy
Assessed early neurological improvement using NIHSS changes at 24-48 hours
Analyzed symptomatic intracranial hemorrhage rates and discharge outcomes
41.2% of patients showed early neurological improvement
54.4% remained neurologically stable while 4.4% had early neurological worsening
Discharge outcomes showed 50.0% improvement, 45.3% stable, and 4.7% worsened
Symptomatic intracranial hemorrhage occurred in only 1 patient, 1.4% of the cohort

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A retrospective cohort study demonstrates tenecteplase improves outcomes in patients with large vessel occlusion, indicating its potential benefits.

Zollos et al. (2026) studied this question.

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A retrospective cohort study demonstrates tenecteplase improves outcomes in patients with large vessel occlusion, indicating its potential benefits.