What question did this study set out to answer?

To evaluate the impact of tenecteplase on functional outcomes in patients with acute ischemic stroke due to non-large vessel occlusion.

May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026ot42 Randomization to Extend Stroke Intravenous Thrombolysis in Evolving Non-Large Vessel Occlusion With TNK - Resilient- Extend-Iv

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To evaluate the impact of tenecteplase on functional outcomes in patients with acute ischemic stroke due to non-large vessel occlusion.
Multicenter, randomized, double-blind, placebo-controlled trial
Patients with acute ischemic stroke treated between 4.5 and 12 hours after last seen well
Eligible participants randomized 1:1 to receive intravenous tenecteplase or standard medical care based on clinical-radiological mismatch.
Primary outcome is a favorable functional outcome at 90 days, adjusted for baseline stroke severity.
Up to 466 participants will be recruited across Brazilian stroke centers.
Interim analyses planned at 40% and 67% enrollment.

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Implication

Randomized trial assesses functional outcomes in acute ischemic stroke patients treated with tenecteplase versus standard care, indicating potential benefits for timely treatment.

Cite This Study

Silva et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e42bfa21ec5bbf0673a https://doi.org/10.1093/esj/aakag023.2063

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Implication

Randomized trial assesses functional outcomes in acute ischemic stroke patients treated with tenecteplase versus standard care, indicating potential benefits for timely treatment.

Abstract Number: Esoc2026ot42 Randomization to Extend Stroke Intravenous Thrombolysis in Evolving Non-Large Vessel Occlusion With TNK - Resilient- Extend-Iv

Key Points

Discussion

Implication

Cite This Study

Abstract Number: Esoc2026ot42 Randomization to Extend Stroke Intravenous Thrombolysis in Evolving Non-Large Vessel Occlusion With TNK - Resilient- Extend-Iv

Key Points

Discussion

Implication

Cite This Study

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