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February 2, 2026

Signaling Pathways Involved in Auditory Hair Cells Development

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Authors

SKShahrokh KhoshsiratNRNavid Ahmady RoozbahanySNSomayeh Niknazar

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Overview

This review examines pathways involved in hair cell development, suggesting potential therapies for hearing loss.

Key Points

  • The aim is to explore the signaling pathways that govern auditory hair cell development and regeneration.
  • Review of existing literature on signaling pathways in hair cell development.
  • Comparison between regenerative abilities in lower vertebrates and mammals.
  • Analysis of therapeutic implications for human hearing loss.
  • Identified key signaling cascades that facilitate auditory hair cell development.
  • Highlighted differences in regenerative capabilities between mammals and lower vertebrates.
  • Suggested pathways that may serve as therapeutic targets for inducing regeneration in humans.

Cite This Study

Khoshsirat et al. (2017) studied this question.

synapsesocial.com/papers/6980ff08c1c9540dea811a42https://doi.org/10.22037/orlfps.v3i1.18238
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances in Understanding the Notch Signaling Pathway in the Cochlea2023 · 2 citations
  2. 2The Field of Hair Cell Regeneration Is Ready for Input from Genomics and Epigenetics2025 · 1 citations
  3. 3The Field of Hair Cell Regeneration Is Ready for Input from Genomics and Epigenetics2025
  4. 4Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ2024 · 10 citations
  5. 5Evolutionary constraints impose multiple checkpoints that block mammalian sensory hair cell regeneration2026