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November 1, 2023Current Pharmaceutical Design

Advances in Understanding the Notch Signaling Pathway in the Cochlea

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Authors

XCXiaoying ChenHWHuanzhi WanYBYutong Bai

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Overview

Narrative review uncovers the role of Notch signaling in cochlear development and hair cell regeneration, highlighting potential therapeutic targets for hearing impairment.

Key Points

  • To review the regulatory functions of the Notch signaling pathway during cochlear development and its potential application in mammalian hair cell regeneration.
  • Synthesized molecular and developmental biology literature evaluating Notch signaling mechanisms in cochlear morphogenesis.
  • Assessed preclinical evidence concerning Notch pathway manipulation for hair cell regeneration following damage from noise exposure or ototoxic agents.
  • Notch signaling acts as a critical molecular regulator directing cell fate and differentiation during embryonic cochlear development.
  • Damage to cochlear hair cells causes irreversible hearing impairment in mature mammals due to their inability to naturally regenerate.
  • Modulation of the Notch signaling pathway demonstrates therapeutic potential to drive hair cell regeneration and alleviate hearing loss.

Cite This Study

Chen et al. (2023) studied this question.

synapsesocial.com/papers/6a79f3df2eb3c7e469f3caabhttps://doi.org/10.2174/0113816128273532231103110910
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Signaling Pathways Involved in Auditory Hair Cells Development2017
  2. 2The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration2025 · 9 citations
  3. 3Live imaging and multimodal profiling reveal transdifferentiation of a cochlear supporting cell subpopulation upon Notch inhibition2026
  4. 4The Field of Hair Cell Regeneration Is Ready for Input from Genomics and Epigenetics2025 · 1 citations
  5. 5The Field of Hair Cell Regeneration Is Ready for Input from Genomics and Epigenetics2025