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September 5, 2025Nature CommunicationsOpen Access

The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration

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Authors

XLXiao-Jun LiCMC. Lloyd MorganLLLin Li

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Overview

Observational analysis shows Jagged1 enhances hair cell formation in supporting cells, indicating its dual role in regeneration.

Key Points

  • Jagged1 enhances hair cell formation capacity in supporting cells, suggesting potential therapy for deafness.
  • Transcriptomic studies indicate that Notch signaling maintains supporting cell characteristics and promotes growth pathways.
  • Notch signaling, activated by Jagged1, prevents supporting cells from becoming hair cells but also sustains their progenitor state.
  • Stimulation of Notch signaling with Jagged1-Fc peptide boosts hair cell formation in both cochlear explants and pre-hearing mice.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d196d6d5674bcd00ad1https://doi.org/10.1038/s41467-025-63053-6
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