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June 19, 2026Science AdvancesOpen Access

Live imaging and multimodal profiling reveal transdifferentiation of a cochlear supporting cell subpopulation upon Notch inhibition

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Authors

LKLama KhalailySKShahar KasirerKDKatherine Domb

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Overview

Randomized trial uncovers transdifferentiation into hair cells in cochlear supporting cells, suggesting new regeneration approaches.

Key Points

  • To define the regenerative potential of cochlear supporting cells and the molecular triggers of transdifferentiation into hair cells.
  • Utilized live imaging and single-cell multiomics of neonatal mouse cochlear explants.
  • Analyzed cellular and molecular characteristics of supporting cells post-Notch inhibition.
  • Transdifferentiating Deiters’ cells initiated hair cell fate upon Notch inhibition.
  • Key supporting cell genes were silenced, distinguishing a rare subpopulation capable of regeneration.
  • Demonstrated coordinated transcriptional and enhancer remodeling linked to morphological changes.

Cite This Study

Khalaily et al. (2026) studied this question.

synapsesocial.com/papers/6a34df4a65a5b0777af2e7cchttps://doi.org/10.1126/sciadv.aed3887
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Field of Hair Cell Regeneration Is Ready for Input from Genomics and Epigenetics2025 · 1 citations
  2. 2The Field of Hair Cell Regeneration Is Ready for Input from Genomics and Epigenetics2025
  3. 3AAV‐mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration2024 · 28 citations
  4. 4MEK/ERK signaling drives the transdifferentiation of supporting cells into functional hair cells by modulating the Notch pathway2024 · 10 citations
  5. 5Evolutionary constraints impose multiple checkpoints that block mammalian sensory hair cell regeneration2026