Key result
Increasing age is linked to opposite LV and RV strain trends for GLS and GRS.
Why the study?
Widespread application of CMR feature-tracking strain assessment is limited by a lack of standardization, population-wide reference values, and data on the effects of sex and age.
Cross-Sectional (n=28,256)
Yes
p-value: p=<0.001
Population-based CMR data demonstrates significant age and sex differences in biventricular myocardial strain, highlighting the need for age- and sex-specific reference values.
Supports age- and sex-specific biventricular strain references in CMR; extends population data but leaves prospective validation open.
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Groeschel et al. (2026) conducted a cross-sectional in Healthy/General Population (n=28,256). Age and sex vs. Different age groups and opposite sex was evaluated on Myocardial strain (LV and RV global longitudinal strain and radial strain) (p=<0.001). Age and sex significantly impacted biventricular myocardial strain, with LV function declining and RV function unexpectedly improving with increasing age (P<0.001 for age and gender effects).
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