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February 2, 2026Current Drug Therapy

Development and Evaluation of a pH-Triggered Aristoflex-Based In-Situ Gel for Sustained Acetazolamide Delivery in Glaucoma Management

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Authors

SBSnehanjana BiswalSiksha O Anusandhan UniversityHPHimansu Sekhor PandaSiksha O Anusandhan UniversityAPAnkita ParmanikSiksha O Anusandhan University

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Implication

Develops an in-situ gel to improve sustained acetazolamide delivery in glaucoma, suggesting enhanced ocular treatment efficacy.

Key Points

  • The central aim is to create a sustained-release gel formulation to improve ocular drug delivery for glaucoma management.
  • Formulations prepared using a cold method and optimized via experimental design software.
  • Evaluated various concentrations focusing on viscosity as the dependent variable.
  • Assessed optimized formulation for clarity, viscosity, pH, and gelling capacity in vitro, ex vivo, and in vivo.
  • Optimized in-situ gel was transparent with a pH of 7.1 and viscosity of 16,327 CP.
  • Formulation switched from sol to gel at ocular pH and demonstrated sustained drug release.
  • Showed effective reduction of intraocular pressure in both in vitro and in vivo studies.

Cite This Study

Biswal et al. (2026) studied this question.

synapsesocial.com/papers/6980fff5c1c9540dea812e07https://doi.org/10.2174/0115748855425376251117071959
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